Multiple sclerosis (MS) is a disease that leads to disability within the central nervous system. MS disrupts the communication channel between the brain and the rest of the organism.
To better understand multiple sclerosis in humans, researchers analyzed mice suffering from a related autoimmune disorder and gauged their response to regenerative therapy. The medical scholars behind the study, experts from the University of California-Irvine, University of Utah, and The Scripps Research Institute (TSRI), observed the rodents walking and running after the stem cells of human beings were introduced to their spinal cords.
The researchers, hopeful that the results of the stem cell therapy study represent a step closer to more reliable MS treatments, presented their findings in Stem Cell Reports on May 15, 2014 (as highlighted in Medical News Today).
Mice able-bodied after regenerative therapy
According to Health Union, 2.5 million people worldwide suffer from multiple sclerosis, with 400,000 of the afflicted in the United States. Women are more likely to experience MS that men are, and Caucasians are more commonly stricken than other races.
Study co-author Dr. Jeanne Loring of Scripps and her colleagues noted that when multiple sclerosis is present, T cells inundate the brain and upper spinal cord, resulting in reduced myelin (a fatty substance that insulates the nerves) and chronic inflammation. As the nervous system degrades, those who experience the disease undergo various symptoms including numbness, impaired vision, and memory loss.
Rejection & recovery following stem cell therapy
As established above, healing achieved by the mice was extraordinary. What makes the results particularly bizarre is that they followed what appeared to be failure: the mice first physically rejected the stem cells since they were human-sourced and (assumedly) perceived as an unknown.
In what is truly a shocking success for regenerative therapy, the researchers implanted the stem cells into paralyzed rodents. Within two weeks, the mice had risen and were mobile. At the end of a few months, the mice were running, completely back to normal.
The other head researcher, Thomas Lane of the University of Utah, mentioned that the particular parameters of this study were what set it apart. After conducting numerous studies on the effects of stem cell therapy in mice, the human cells sourced by the TSRI lab performed much more strongly than any cells previously tested.
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